Сharacteristics of proliferation and differentiation of erythroid progenitor cells at chronic myeloid Leukemia in cells culture in vivo

I. Sviezhentseva, D. Bilko, N. Bilko, I. Dyagil
The National University of "Kyiv-Mohyla Academy", Kyiv; The National University of "Kyiv-Mohyla Academy", Kyiv; The National University of "Kyiv-Mohyla Academy", Kyiv; SI"National Research Center for Radiation Medicine of the NAMS of Ukraine", Kyiv

Abstract


The article presents a study of proliferation and differentiation features of erythroid progenitor cells of patients with chronic myeloid leukemia during the treatment with tyrosine kinase inhibitors – imatinib and nilotinib. The cultivation results showed an increase in proliferative activity of erythropoiesis progenitor cells both in the case of patients with leukemia, diagnosed for the first time, and in the case of bone marrow samples of patients with a resistance of leukemic cells clone to treatment with tyrosine kinase inhibitors. Moreover, the results showed an inhibition of erythroid progenitor cell differentiation and acquisition of resistance to tyrosine kinase inhibitors by leukemic cells clone.


Keywords


chronic myeloid leukemia, erythroid progenitor cells, cell culture in vivo, tyrosine kinase inhibitors

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DOI: http://dx.doi.org/10.17721/2616_6410.2016.20.65-68

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