Structural changes of spinal cord fibrosis due to epidural application of mixture of longidaza and diprospa

Ya. Fishchenko, D. Zavodovskyi, T. Matvienko, D. Nozdrenko, O. Motuzyuk
DU "Institute of traumatology and orthopedics of AMN of Ukraine", Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Eastern European National University named after Lesia Ukrainka, Lutsk

Abstract


Changes in structure of fibrosis of rat spinal cord induced using intervertebral disc rupture fibers method due to application longidaza and diprospan mixture. Simultanious epidural application of hyaluronidase and betamethasone in preparation of diprospan and longidasa had high synergistic effect and antifibrosis activity. Through anti-inflammatory effect and ability to reduce epidural scars adhesion this complex, to our opinion, has perspective in therapy of epidural spinal cord fibrosis.


Keywords


fibrosis, connective tissue, longidaza, diprospan

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DOI: http://dx.doi.org/10.17721/2616_6410.2016.20.49-53

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