Tyrosyl-tRNA Synthetase and its Separated Domains are Suppositional Components of Prostate Cancer Pathogenesis

M. Grom, L. Yakovenko, L. Sidorik, O. Kornelyuk, V. Grygorenko, M. Vikarchuk
Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Kyiv; Institute of Molecular Biology and Genetics NAS of Ukraine, Kyiv; Institute of Molecular Biology and Genetics NAS of Ukraine, Kyiv; Institute of Molecular Biology and Genetics NAS of Ukraine, Kyiv; SI Institute of Urology NMAS of Ukraine, Kyiv; SI Institute of Urology NMAS of Ukraine, Kyiv


Elevated levels of autoantibodies against tyrosyl-tRNA synthease and its separated fragments enriched with proinflammatory and angiogenic properties in sera of patients with prostate cancer were shown. In serum samples of patients the highest levels of autoantibodies against C-terminal domain were observed. Minimal autoreactivity among persons with oncopathology was shown against N-terminal domain of tyrosyl-tRNA synthetase.


tyrosyl-tRNA synthetase, autoantibodies, prostate cancer

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DOI: http://dx.doi.org/10.17721/2616_6410.2016.20.38-44


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