Investigation of erythrocyte aggregation in patients with laryngeal cancer

Yu. Burlaka, N. Gryn, O. Goloborodko, S. Verevka
National Academy of Medical Sciences of Ukraine prof. O.S. Kolomiychenko Institute of Otolaryngology, Kyiv; National Academy of Medical Sciences of Ukraine prof. O.S. Kolomiychenko Institute of Otolaryngology, Kyiv; National Academy of Medical Sciences of Ukraine prof. O.S. Kolomiychenko Institute of Otolaryngology, Kyiv; National Academy of Medical Sciences of Ukraine prof. O.S. Kolomiychenko Institute of Otolaryngology, Kyiv

Abstract


It was compared evaluation of results of erythrocytes aggregation parameters in patients with laryngeal cancer compared to the healthy persons. It was found that in patients with laryngeal cancer II-d and III-d stage of the tumor process against the background of increasing the degree of aggregation and the time relative to the corresponding reference data, there is a simultaneous decrease in its speed of aggregation. In addition, the study has shown increase in average weight molecules and fibrinogen levels in the blood plasma of patients with laryngeal cancer, to a lesser extent – with the II-d stage of the disease, and their more significant violations were observed in the III-d stage of the cancer process. Sialic acid content was increased at II and III-d stages of cancer of the larynx in the same degree compared to the healthy persons. It was established
opposite changes of basic parameters of erythrocytes aggregation. The most significant violations of aggregation degree were observed in the II-d stage of the cancer process. Growing of levels of the average weight molecules, fibrinogen and sialic acid in the blood plasma of patients with laryngeal cancer indicates the presence of metabolic intoxication and the acute phase of inflammation, the severity of which to a certain extent depends on the stage of the disease.


Keywords


laryngeal cancer, erythrocytes, aggregation, average weight molecules, fibrinogen, sialic acid

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DOI: http://dx.doi.org/10.17721/2616_6410.2016.20.34-38

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