Risk factors for hemostatic imbalance in patients with inflammatory diseases andneoplasms of ENT organs

Yu. Klys, S. Verevka, T. Halenova, T. Vovk
National Academy of Medical Sciences of Ukraine prof. O.S. Kolomiychenko Institute of otolaryngology, Kyiv; National Academy of Medical Sciences of Ukraine prof. O.S. Kolomiychenko Institute of otolaryngology, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv

Abstract


To undertake a comparative study of some components of haemostatic system in patients with inflammatory diseases and tumors of URT for clarification of their role in pathologic process and for reveal of their informative value for evaluation of the pathologic process' flow. The indices of prothrombine pool, content of tissue activator of plasminogen, inhibitor of plasminogen's acnivator PAI-1, and von Willebrandt factor were tested in groups of patients with inflammatory diseases and tumors of URT-organs in contrast of the same ones in the group healthy donors as well as dependently to the kind and stage of disease. The informative value of all the tested indices as well as their dependence of the kind and the stage of disease were proved. Their differences from the norm prove for deep alterations in haemostatic system's functioning at considered diseases. Obtained data seems to be promising for complex evaluation of the state of patients with inflammatory diseases and tumors of URT-organs.


Keywords


inflammations, tumors, haemostatic system

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DOI: http://dx.doi.org/10.17721/2616_6410.2016.20.19-22

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