Kisspeptin-mediated regulation of the morpho-functional state of the rat testicles under the effect of silver nanoparticles

V. Kalinovskyi, A. Pustovalov, M. Dzerzhynskyi, G. Grodzyuk, N. Andriushina
Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Nanomedtech-LLC, Kyiv; Nanomedtech-LLC, Kyiv

Abstract


It was shown that silver nanoparticles downregulate reproductive system of male rats. At the same time, activation of the hypothalamic sex-function regulatory center did not result in any stimulatory effect on testes. We suppose that toxicity of silver nanoparticles is due to their direct action on the testicles.


Keywords


nanoparticles, silver, kisspeptin, testis

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References


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DOI: http://dx.doi.org/10.17721/2616_6410.2016.20.8-11

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