Morphological features of the mucous membrane of the colon of patients with early and late ulcerative colitis debut

A. Dorofeeva

Abstract


The purpose of the research was to determine the morphological features of the mucous membrane of the large intestine of patients with UC depending on the age of patients. A comparative analysis of the incidence and type of UC of patients with early onset and late debut of the disease was performed. It has been stated that for patients with a debilitating post-traumatic disorder, the left ventricular and total forms are characteristic; in patients with late debut, the distal form of UC predominates. The main trends in the activity of UC in patients with early onset and late debut have been determined. In the analysis of the degree of activity of UC revealed that in patients from 50 years of age and older, with the late debut of the disease, the first one is mostly found to be the least degree of activity, the second – the middle and the third – the high degree, they are found to be less likely. In turn, in patients under 50, the second and third stages of the disease are most often noted. Another component of the main characteristics of the UC was the histological changes of the mucous membrane of the large intestine. Thus, the conducted studies allowed to state that the number of PAS-positive substances in mucus is significantly higher in patients with distal and left-sided UC. In patients with UC there is a marked mucosal intestinal mucosa of qualitative and quantitative composition of mucus. These changes were characterized by a decrease in MUC2 as
the disease progressed, as well as levels of MUC4 and TFF3. In patients with early onset of NSC, there is a more intense reduction in the number of mucins and TFF3 already with a minimal activity of UC associated with low levels of mucin from the intracellular mucus and indicates a more aggressive course of it. At the same time, patients with a late debut revealed a sharp decrease in the number of MUC2 and TFF3 with high activity of UC.

Keywords


non-specific ulcerative colitis, early and late debut, NSC form, histological changes, mucus formation

Full Text:

PDF>PDF

References


Sіmonova O. V. Stan tovstoїkishki і verhnіh vіddіlіv shlunkovo kishkovogo traktu za endoskopіchnimi danimi u hvorih na nespecifіchnij virazkovij kolіt і hvorobu krona z anemіchnim sindromom / Sіmonova O.V., Bojko T. J. // Gastroenterologіya. – № 2(48). – S. 86–90.

Cimmerman YA. S. Yаzvennyj koliti bolezn' Krona: sovremennye predstavleniya chast' 1. definiciya, terminologiya, rasprostranennost', ehtiologiya i patogenez, klinika, oslozhneniya, klassifikaciya / YA. S. Cimmerman, I. YA. Cimmerman, YU. I. Tret'yakova // ZHurnal Klinicheskaya medicina. – 2013. – № 11. – S. 31.

Stepanov YU. M. Dinamіka zahvoryuvanostі ta poshirenostі osnovnih hvorob organіv travlennya v Ukraїnіza 5 ostannіh rokіv / YU. M. Stepanov // Gastroenterologіya: mіzhvіd. zb. – D.: ZHurfond, 2012. – S. 3–12.

Dorofєєva G. A., Vasilenko І. V., Dorofєєv A. E., Dyadik O. O., Derkach І.A. Morfologіchnі aspekti dіagnostiki nespecifіchnogo virazkovogo kolіtu: suchasnij poglyad na problemu // Suchasna gastroenterologіya № 4 (96) 2017, Kiїv.

Stepanov YU. M. Soderzhanie fekal'nogo kal'protektina u bol'nyh hronicheskimi vospalitel'nymi zabolevaniyami kishechnika / YU. M. Stepanov, N. S. Fedorova // Suchasna gastroenterologіya. – № 2. – 2010. – S. 44–48.

Stepanov YU. M. Realii i perspektivy v diagnostike zabolevanij kishechnika / YU. M. Stepanov, N. S. Fedorova // Suchasna

gastroenterologіya. – 2010. – № 1. – S. 109–114.

Zou L., Wang L., Gong X. et al. The association between three promoter polymorphisms of IL-10 and inflammatory bowel diseases (IBD): a meta-analysis // Autoimmunity. – 2014. – Vol. 47(1). – P. 27–39.

Sartor RB. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol. 2006; 3(7): 390–407.

Moćko P., Kawalec P., Pilc A. Safety profile of biologic drugs in the treatment of inflammatory bowel diseases: A systematic review and network meta-analysis of randomized controlled trials // Clin Drug Investig. – 2017. – Vol. 37(1). – P. 25–37.

Perez-Vilar J. Mucin granule intraluminal organization // Am J Respir Cell Mol Biol. – 2008. – № 36 (2). – R. 183–190.

Received: 01.03.2019

Revised: 02.04.2019

Signed in the press: 02.04.2019




DOI: http://dx.doi.org/10.17721/1728_2624.2019.26.12-17

Refbacks

  • There are currently no refbacks.


Лицензия Creative Commons
This journal is available according to the Creative Commons License «Attribution» («Атрибуція») 4.0 Global (CC-BY).