Antineoplastic, anti-metastatic and metabolic effects of newly synthesized platinum complexes

A. Biliuk, L. Garmanchuk, O. Skachkova, H. Repich, S. Orysyk
ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, Kyiv; ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, Kyiv; Ukrainian National Cancer Institute, Kiyv; Institute of general and inorganic chemistry of Natl. Acad. Sci. of Ukraine, Kiyv; Institute of general and inorganic chemistry of Natl. Acad. Sci. of Ukraine, Kiyv

Abstract


The aim of this work was to study the antitumor, anti-metastatic and metabolic effects of the newly synthesized n, π-chelate complexes Pt2+ with N-allythioureas (complex II and IU complex). The studies used high-metastable strain of transfected Lewis lung carcinoma and HepG2-transformed hepatocyte cells with high activity gamma-glutamate transpeptidases and mouse leukemia cells of L1210 with pronounced aneuploid karyotype and short duplication of population. In the comparative analysis with the classical chemotherapy cisplatin, the II and IV complexes revealed antitumor and anti-metastatic effects and normalization of biochemical disorders, which are confirmed by a decrease in the activity of lactate
dehydrogenase and gamma-glutamine transpeptidase, indicating the inhibition of the formation of drug resistance.


Keywords


n, π-chelate complexes Pt2 + with N-allylthioxides, antitumor and anti-metastatic action, gamaglutamintranspeptidase antiviability

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DOI: http://dx.doi.org/10.17721/2616_6410.2017.23.69-75

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