Influence of C60FAS on the speed-power parameters of the tetanic contraction of muscle soleus on the conditions of experimentally-induced ischemia at different durations in alcoholised rats

S. Zay, O. Motuzyuk, V. Belobrov, D. Vulitska, O. Nozdrenko
Lesya Ukrainka Eastern European National University, Lutsk; Lesya Ukrainka Eastern European National University, Lutsk; ESC "Institute of biology and medicine" Taras Shevchenko National University of Kyiv, Kiev; ESC "Institute of biology and medicine" Taras Shevchenko National University of Kyiv, Kiev; Bogomolets National Medical University, Kiev,

Abstract


In the article presented the results of tenzometric studies of the effect of C60FAS (concentration 0.15 mg / ml) at a dose of 1 mg / kg ON the speed-power parameters of the tetanic reduction of muscle soleus under conditions of ischemia in chronic alcoholic rats during 1-hour and 2-hour. The synergistic effect of ischemic injury and alcoholic intoxication, as compared to the native muscle, is manifested in reducing the reduction power to 26,25 ± 3,23 and 20,2 ± 2,45 (p≤0,01), and an increase in the time to achieve it the maximum values for 1.33 ± 0.12s and 1.45 ± 0.15s (p≤0.01) respectively. It is shown that if the intraperitoneal administration of the VRC60 solution is given, these indices are likely to increase.


Keywords


fullerenes, ischemia, chronic alcoholism, muscle soleus

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DOI: http://dx.doi.org/10.17721/2616_6410.2017.23.59-65

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