Biochemical changes in blood serum of rats with experimental esophageal burn II degree under treatment with aqueous extract of P. vulgaris pods

V. Dmytryk, Ya. Raetska
ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, Kyiv; ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, Kyiv


During modeling of esophageal alkali burns II degree in immature rats were observed violations of various metabolic systems. It was shown that under the esophageal burns there occurred violations of protein (total protein, albumin), nitrogen metabolism (creatinine, urea), changed the activity of enzymes (GOT, GPT), violated fluid and electrolyte balance (Na+, К+, Cl-, Ca2+, Mg2+). In the groups of animals with the alkaline burn of the esophagus, that were injected aqueous extract of pod of bean (Phaseolus vulgaris) there can be traced a change of the indicators in the direction of normalization, indicating about the obvious therapeutic effect of aqueous extract of pod of bean (Phaseolus vulgaris).


esophageal burn, biochemical parameters, metabolism, polyphenols, aqueous extract of pod of bean (Phaseolus vulgaris)

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Klimenko M., Netyuhaylo L. Burn disease (pathogenesis and treatment). 2009. 118 p.

Raetska Y., Ishchuk T., Savchuk O., Ostapchenko L. Experimental modeling of first-degree chemically-induced esophageal burns in rats. Medical chemistry; 2013. 15, № 4. P. 30-34.

Samojlenko G. Burns in children. Child Health; 2006. V.1. P. 111-115.

Stefanov O. Doklinichni doslidzhennya likars'kykh zasobiv: Metod. Rekomendatsiyi Derzh. farmakol. tsentr. K.: Vyd. dim "Avitsena"; 2001. P. 256-262.

Fistal E., Kozinets G., Samoilenko G. et al. Combustiology. Kharkov; 2004. P.184.

Adam J., Birck H. Pediatric caustic ingestion. Ann OtolRhinol Laryngol, 1982. V.91: P. 656–658.

Akbal E., Köklü S., Karaca G. et al. Beneficial effects of Ankaferd blood stopper on caustic esophageal injuries: an experimental model. Dis Esophagus 2012; 25: P.188–94

Alov P., Tsakovska I., Pajeva I. Computational studies of free radical-scavenging properties of phenolic compounds. Curr. Top. Med. Chem; 2015. 15. Р. 85–104.

Anindita K., Arka G., Narendra K., Gireesh K., Ankit S., Santosh K., Siva H., Damiki L. Wound healing activity of the ethanol root extract and polyphenolic rich fraction from Potentilla fulgens. Taylor & Francis,

54 ed., 2016. P. 2383-2393.

Bahramsoltani R., Farzaei M., Rahimi R. Medicinal plants and their natural components as future drugs for the treatment of burn wounds: An integrative review. Arch. Dermatol. Res; 2014. 306. Р. 601–617.

Bakan V., Garipardic M., Okumus M. et al. The protective effectof erythropoietin on the acute phase of corrosive esophagealburns in a rat model. Pediatr Surg Int 2010; 26: P. 195–201

Barrett ML, Udani JK. A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): a review of clinical studies on weight loss and glycemic control. Nutr J. 2011 Mar;17(10):24. P. 24.

Contini S. Oesophageal corrosive injuries in children: a forgotten social and health challenge in developing countries. B. Wor. Heal. Org. – 2009. –Vol. 87, № 12. – P. 950 – 954.

Chornenka N., Raetska Y., Savchuk O., Torgalo E., Beregova T., Ostapchenko L. Correction Parameters of Endogenous Intoxication in Experimental Burn Disease at the Stage of Toxemia. RJPBCS 7(5), September – October; 2016. Р.1042

Ercan S., Nihat M. The Effect of Pepper Gas (OC) on Some Biochemical Parameters in Rats. Kafkas Univ Vet Fak Derg; 2012. 18 (2); Р. 259-266.

Gokakin A., Deveci K., Kurt A., Karakus B., Duger C. The protective effects of sildenafil in acute lung injury in a rat modelof severe scald burn: A biochemical and histopathological study. Burns; 2013; V – 39: P. 1193.

Gundogdu H., Tanyel F., Buyukpamukcu N., Conservative treatment of caustic esophageal strictures. J Pediatr Surg, 1992. 27. P. 767–770

Hawkins D., Demeter M., Bornett T. Caustic ingestion – controversies in management: a review of 214 cases.Laryngoscope,1980. V. 90. P.98–109

Ishchuk T., Raetska Y., Savchuk O., Ostapchenko L. Changes in blood protein composition under experimental chemical burns of esophageal development in rats. Biomedical Research and Therapy; 2015. 2(4). Р. 241-249

Jeschke M. The Hepatic Response to Thermal Injury: Is the Liver Important for Postburn Outcomes? Molecular Medicine. 2009;15(9-10). P. 337-351.

Karnak I., Tanyel F., Büyükpamukçu N., Hiçsönmez A. Combined use of steroid, antibiotics and early bougienage againststricture formation following caustic esophageal burns. JCardiovasc Surg (Torino) 1999; 40. P. 307–10.

Kyznetsova M., Makieieva O., Lavrovska D., Tymoshenko M., Sheverova D., Halenova T., Savchuk O., Ostapchenko L. Effect of Aqueous Extract from Phaseolus vulgaris Pods on Lipid Peroxidation and Antioxidant Enzymes Activity in the Liver and Kidney of Diabetic Rats. Journal of Applied Pharmaceutical Science. 2015 May;5(5). P.1-6.

Mantle D. Adverse and beneficial effects of plant extracts on skin and skin disorders. Pharmaceutical biology Adverse Drug React Toxicol Rev., 2001. vol. 20. P. 89–103.

Mutaf O. Treatment of corrosive esophageal strictures by longterm stenting. J Pediatr Surg 1996; V.31. P.681

Nayci A., Cakmak M., Renda N., Erekul S. The effect ofcorticosteroids and pentoxiflline in inhibition of wound healing incorrosive esophageal burns: a prospective randomised trial in rats. Int J Surg,1997.82. P. 371–375.

Pintus C., Manzoni C., Nappo S., Perrelli L. Caustic ingestion in childhood: current treatment possibilities and their complications. Pediatr Surg Int,1993. 8. P.109–112.

Tander B., Baskaya H., Ariturk E., Rizalar R. Balon dilatation in esophageal stricures. In: Colloquium on gastroesophageal reflux and esophageal strictures. Izmir, Turkey, 2003. P. 1-5.

Waxman K., Rebello T., Pinderski L., O'Neal K., Khan N., Tourangeau S. Protein loss across burn wounds. J Trauma 1987. N–27–P. 136–140.

Yousef I., El-Demerdash M., Radwan F. Sodium arsenite induced biochemical perturbations in rats: Ameliorating effect of curcumin. FoodChemToxicol; 2008 – N.48 – Р. 3506.



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