REACTION OF LYMPHOIDAL ORGANS OF RATS TOTHE GROWTH OF GLIOMA C6

I. Opeida, M. Rudyk, V. Svyatetska, L. Skivka, O. Fedorchuk
; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine,; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine,; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine,; Kavetsky Institute of Experimental pathology, onkology and radiobiology, NASU, Kyiv, Ukraine

Abstract


The study of the responce of peripheral lymphoid structures to the presence of malignant tumor in the brain offers the challenge for the use of immunotherapeutic approaches for the treatment of this disease. This work was aimed to evaluate weight indices and cellularity of lymphoid organs in rat with C6 glioma. One was found that the growth of glioma is accompanied by changes in the cellularity of the organs of the lymphatic system. The observed changes indicate the likelihood of the presentation of C6 glioma antigens in peripheral lymphoid structures, as well as the negative impact of glioma growth on thymus and spleen homeostasis.


Keywords


lymphoid organs; glioma; cellularity of the organ; mass index

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