CORRECTION OF MELANIN PROTEOLYTIC ACTIVITY IN THE CONDITIONS OF MODELING ALKALI BURNS OF THE ESOPHAGUS

N. Chornenka, K. Valetska, Ya. Rayetska, L. Ostapchenko
Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine

Abstract


During the esophageal burns first and second degree, were observed the increase of total proteolytic activity and of the main proteinase (metalloproteinases and serine). Experimental melanin correction at a dose of 0.1 mg / kg contributed to the normalization of the pathological increase of total proteolytic activity and the activity of the main proteinase (metalloproteinases and serine), which indicates the normalization of the proteolysis system. 


Keywords


alkaline burn of the esophagus; proteolysis; melanin

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