State of glutathione system in the serum of rats in experimental osteoarthritis and administration of chondroitin sulphate

E. Tikhova, M. Tymoshenko, Y. Kovelska, K. Dvorshchenko
; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine


It was established that in osteoarthritis induced by administering of sodium monoiodacetate in the blood serum of rats glutathione system enzyme activities reduced – glutathione peroxidase, glutathione, oxidized glutathione and the ratio of redox glutathione forms moved towards oxidation. It has been found that after the introduction of the drug based on the sodium chondroitin sulphate enzyme activities grew and glutathione balance normalized in the serum of rats with chemically induced osteoarthritis.


osteoarthritis; oxidation; glutathione; chondroitin sulfate


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