State of hyperglycemic animals during consumption of high-calorie diet with the bionanocomposite supplement

Ie. Goloborodko, V. Konopelniuk, L. Ostapchenko
Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine


Glucose level and glucose tolerance test in blood of rats under conditions of obesity induced by consumption of high-calorie diet have been determined. It was also researched these indicators in the blood of animals that consumpt high-calorie diet with added bionanocomposite. These data suggest bionanocomposite preventive effect on the development of key indicators prediabetes.


glucose; glucose tolerance test; bionanocomposite; prevention; obesity

Full Text:



Barness L.A., Opitz J.M., Gilbert-Barness E. Obesity: Genetic, molecular, and environmental aspects. Med Genet. 2007;143:3016-34.

Rimmer J.H., Yamaki K., Lowry B.M., Wang E., Vogel L.C. Obesity and obesity-related secondary conditions in adolescents with intellectual developmental disabilities. J Intellect Disabil Res. 2010;54(9):787-94.

Onakpoya I., Posadzki P., Ernst E. Chromium supplementation in overweight and obesity: a systematic review and meta-analysis of randomized clinical trials. Obes Rev. 2013;14(6):496-507.

McClean KM, Kee F, Young IS, Elborn JS. Obesity and the lung: 1. Epidemiology. Thorax 2008;63:649-54.

Singh S, Mishra S. Potential of Herbs in Prevention of Obesity- A Review Article. IJHSR. 2013; 3(12):159-167.

Satheeshkumar N, Mukherjee PK, Bhadra S, et al. Acetylcholinesterase enzyme inhibitory potential of standardized extract of Trigonella foenum graecum L and its constituents. Phytomedicine.2010; 17(3-4):292-295.

Yosra Belaпd-Nouira, Hayfa Bakhta, Zohra Haouas, et al. Fenugreek seeds reduce aluminum toxicity associated with renal failure in rats Nutr Res Pract. 2013; 7(6):466-474.

Sajad Arshadi, Salar Bakhtiyari, Karimeh Haghani, et al. Effects of Fenugreek Seed Extract and Swimming Endurance Training on Plasma Glucose and Cardiac Antioxidant Enzymes Activity in Streptozotocininduced Diabetic Rats Osong Public Health Res Perspect. 2015; 6(2):87-93.

Neeraja A, Rajyalakshmi P. Hypoglycemic effect of processed fenugreek seeds in humans. J Food Sci Technol. 1996; 33:427-430.

T. P. Karpovets, V. V. Konopelnyuk, T. I. Galenova, A. N. Savchuk, and L. I. Ostapchenko.High-Calorie Diet as a Factor of Prediabetes Development in Rats. Bulletin of Experimental Biology and Medicine. 2013; 156(5):639-641.

Karpovets TP, Konopelnyuk VV, Savchuk OM, Ostapchenko LI. Food behavior of rats under development of obesity. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2014; 5(5):253-259.

Konopelnyuk V, Yurchenko A, Karpovets T, Ostapchenko L. The development of obesity and prediabetes under conditions of longterm consumption of fructose solution in rats. Journal of Applied Pharmaceutical Science. 2015; 5(1):001-005.

Xіu-Huа Shеn, Qіng-Yа Tаng, Juаn Huаng, Wеі Cаі. Vіtаmіn Е rеgulаtеs аdіpоcytоkіnе еxprеssіоn іn а rаt mоdеl оf dіеtаry-іnducеd оbеsіty. Еxpеrіmеntаl Bіоlоgy аnd Mеdіcіnе. 2010; 235:47-51.

Yuli Huang, Xiaoyan Cai, Weiyi Mai, Meijun Li, Yunzhao Hu. Association between prediabetes and risk of cardiovascular disease and all cause mortality: systematic review and meta-analysis BMJ. 2016; 355: i5953.

DeFronzo RA, Abdul-Ghani M. Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose. Am J Cardiol. 2011;108(Suppl):3B 24B.

World Health Organization (WHO) Consultation. Definition and diagnosis of diabetes and intermediate hyperglycaemia. 2006

Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2003;26(Suppl 1):S5-20.



  • There are currently no refbacks.

Лицензия Creative Commons
This journal is available according to the Creative Commons License «Attribution» («Атрибуція») 4.0 Global (CC-BY).