АGE CHARACTERISTICS OF ACTIVITY SOME COMPONENTS OF PROTEOLYSIS IN BREAST TISSUES

N. Motruk

Abstract


The activity of proteolytic enzymes and their inhibitors in breast samples of women of different age was investigated. It was shown that the activity of some components of the proteolytic system in maligmant and nonmalignant breast tissues is substantially depend on the age of women and the development of tumor. Activity of inhibitor of trypsine was determined only by age of women and did not depend on the degree of oncoprocess. Аctivities of cathepsin-D- and cathepsin-L-like proteinases, matrix metalloproteinase-2, trypsine-like proteinase and carboxypeptidase A determined by development of oncoprocess and does not depend on age of women.


Keywords


cathepsin H; tumor; mammary gland; substrate specifity

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