Age-related physiological and biochemical changes in Drosophila grown on alpha-ketoglutarate

M. Lylyk, O. Sorochynska, O. Maniukh, M. Bayliak
; Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine; Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine; Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine


In the work, certain metabolic parameters and parameters of functional senescence were studied in the fruit fly D. melanogaster w1118 males fed with alpha-ketoglutarate (AKG). Dietary increased levels of amino acids and protein in 2-day-old males and levels of triacylglycerols in 24-day-old males with no effect on antioxidant system of males of both age groups. In addition, AKG-supplemented food increased resistance to heat stress but not to oxidants in both age groups and prevented the decline in locomotor activity in middle-aged males.


amino acids; triacylglycerols; heat stress; locomotor activity


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