Expression of AQP8 gene in rat duodenum with diarrhea upon long-term gastric hypochlorhydria

A. Dranitsina, K. Dvorshchenko, D. Grebinyk, L. Ostapchenko
; Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv


The decreasing of Aqp8 gene's expression in rat duodenal villus and crypt epithelial cells against the background of intensification of free radical formation with diarrhea upon gastric hypoacidic conditions were shown. The level of above mentioned gene's expression both in villus and crypt epitheliocytes approached to the control value upon the treatment of hypoacidic rats with multiprobiotic Symbiter.


gastric hypoacidity; duodenal; diarrhea; gene expression; Aqp8; multiprobiotic


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