ACTION OF CHONDROITIN SULFATE ON THE LEVEL OF CYTOKINES AND REACTIVE OXYGEN SPECIES IN BLOOD SERUM AT CARRAGEENAN-INDUCED INFLAMMATION

К. Dvorshchenko, M. Ashpin, O. Korotkyi, Ye. Torgalo, T. Falalyeyeva
; Taras Schevchenko National University of Kyiv, Kyiv, Ukraine; Taras Schevchenko National University of Kyiv, Kyiv, Ukraine; Taras Schevchenko National University of Kyiv, Kyiv, Ukraine; Taras Schevchenko National University of Kyiv, Kyiv, Ukraine

Abstract


Increase of concentration of pro-inflammatory cytokines (IL-1β, TNF-α) is fixed in blood serum at carrageenan-induced rat paw inflammation, as well as increase of the content of reactive oxygen species (superoxide radical, hydrogen peroxide). At introduction of the preparation on the basis of chondroitin sulfate the level of pro-inflammatory cytokines and reactive oxygen species in blood serum decreases, while the concentration of IL10 increases in 1,7 times concerning the group of animals with сarrageenan-induced inflammation.

Keywords


сarrageenan-induced inflammation, blood serum, pro-inflammatory cytokines

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