The activity of succinatedehydrogenase and cytochromeoxidase in primary culture in oculated Lewis lung carcinoma on various stages of tumor growth

A. Biliuk, A. Nehelia, L. Garmanchuk, O. Skachkova
Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; National Cancer Center, Kyiv

Abstract


It was established that cytochromeoxidase activity of Lewis carcinomaprimary culture at 14thday was 2,4 ± 0,15 mmolcyt.c/mg*min, and it was decrease dalmostat 7-fold (p <0.01) at 25thday, where as succinate dehydrogenase activity at 25thday was decreased to 21.7 ± 2.3mmolK3 [Fe (CN)6]/mg*min, which was at 1.6 fold less than at 14thday.

Keywords


cytochrome oxidase, succinate dehydrogenase, Lewis lung carcinoma, tumor, cancer, mitochondria, oxidative stress, aneuploidy

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DOI: http://dx.doi.org/10.17721/2616_6410.2016.21.81-85

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