Age features of metabolic syndrome effects on fetal embryonic development of the male rat offsprings

O. Tkachenko, V. Kovalenko
State Institution ""Institute of Pharmacology and Toxicology of NAMS of Ukraine", Kyiv; State Institution ""Institute of Pharmacology and Toxicology of NAMS of Ukraine", Kyiv


Comparative study of embryo-fetal death in females fertilized by males with metabolic syndrome, induced in adult or juvenile age has shown that the offspring of adult rats did not have significant abnormalities in embrio- and fetogenesis. At the same time it has been revealed 4% postimplantation death of offspring in male rats with metabolic syndrome induced in the juvenile age. The pre-implantation loss in this group was 6 folds higher than in control. Accordingly, the total mortality of the offspring rose 2.4 times in comparison with control.

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