Protein kinase C participation in the mechanisms of vascular tone disturbance upon diabetes mellitus. Part 4

I. Kizub, O. Kharchenko, O. Kostiuk, L. Ostapchenko, K. Klymenko, A. Soloviev
Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; State Institution "Institute of Pharmacology and Toxicology of NAMS of Ukraine", Kyiv; State Institution "Institute of Pharmacology and Toxicology of NAMS of Ukraine", Kyiv

Abstract


Diabetes mellitus (DM) is acompaining by vascular tone desorders development. Regulatory enzyme protein kinase C (PKC) is involved in mechanisms of these desorders development. Numerous studies have demonstrated that contractile responces of vascular smooth muscle are enchansed in DM and endothelium-independent PKC-mediated mechanisms are involved in this process. Such mechanisms are PKC-mediated inhibition of Ca2+ activated K+ channels (BKCa) in vascular smooth muscle cells (SMCs) and SMCs myophilaments Ca2+ sensitization. PKC is a potential therapeutic target for treating vascular diabetic complications. A few compounds among PKC inhibitors already exist, such as ruboxistaurin, indolylmaleimide and its derivatives. Recently discovered method of RNA-interference (RNAi) is an essential gene-silencing tool and can also be used for PKC inhibition and DMassociated vascular complicaions elimination.

Keywords


diabetes mellitus, protein kinase C, vascular tone, vascular smooth muscle, Ca2+ sensitization, RNA-interference

Full Text:

PDF>PDF

References


Aiello LP, Vignati L, Sheetz MJ, Zhi X, Girach A, Davis MD, et al. Oral protein kinase C β inhibition using ruboxistaurin: efficacy, safety, and causes of vision loss among 813 patients (1,392 eyes) with diabetic retinopathy in the protein kinase C β inhibitor-diabetic retinopathy study and the protein kinase C β inhibitor-diabtic retinopathy study 2. Retina 2011;31:2084–94. PubMed PMID: 21862954.

Akhtar S, Yousif MHM, Dhaunsi GS, Sarkhouh F, Chandrasekhar B, Attur S, et al. Activation of ErbB2 and downstream signalling via Rho kinases and ERK1/2 contributes to diabetes-induced vascular dysfunction. PLoS One 2013;8(6):e67813. PubMed PMID: 23826343.

Balasubramanyam M, Balaji RA, Subashini B, Mohan V. Evidence for mechanistic alterations of Ca2+ homeostasis in type 2 diabetes mellitus. Int J Exp Diabetes Res 2001;1:275–87. PubMed PMID: 11467418.

Bansal D, Badhan Y, Gudala K, Schifano F. Ruboxistaurin for the treatment of diabetic peripheral neuropathy: a systematic review of randomized clinical trials. Diabetes Metab J 2013;37:375–84. PubMed Central PMCID: PMC3816139.

Caplen NJ, Parrish S, Imani F, Fire A, Morgan RA. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc Natl Acad Sci USA 2001;98:9742–7. PubMed PMID: 11481446.

Chow WL, Zhang L, MacLeod KM. Noradrenaline-induced changes in intracellular Ca2+ and tension in mesenteric arteries from diabetic rats. Br J Pharmacol 2001;134:179–87. PubMed Central PMCID: PMC1572921.

Cicek FA, Kandilci HB, Turan B. Role of ROCK upregulation in endothelial and smooth muscle vascular functions in diabetic rat aorta. Cardiovasc Diabetol 2013;12:51. PubMed PMID: 23530857.

Curtis TM, Major EH, Trimble ER, Scholfield CN. Diabetes induced activation of protein kinase C inhibits store-operated Ca2+ uptake in rat retinal microvascular smooth muscle. Diabetologia 2003;46:1252–9. PubMed PMID: 12898009.

Danis RP, Sheetz MJ. Ruboxistaurin: PKC-β inhibition for complications of diabetes. Expert Opin Pharmacother 2009;10(17):2913–25. PubMed PMID: 19929710.

Davel AP, Rossoni LV, Vassallo DV. Effects of ouabain on the pressor response to phenylephrine and on the sodium pump activity in diabetic rats. Eur J Pharmacol 2000;406:419–27.

Dimitroloulou C, Han G, Miller A, Molero M, Fuchs LC, White RE, et al. Potasium (BKCa) currents are reduced in microvascular smooth muscle cells from insulin-resistant rats. Am J Physiol Heart Circ Physiol 2002;282:908–17. PubMed PMID: 11834486.

Eto M. Regulation of cellular protein phosphatase-1 (PP1) by phosphorylation of the CPI-17 family, C-kinase-activated PP1 inhibitors. J Biol Chem 2009;284:35273–7. PubMed Central PMCID: PMC2790955.

Feng J, Ito M, Ichikawa K, Isaka N, Nishikawa M, Hartshorne DJ, et al. Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. J Biol Chem 1999;274:37385–90. PubMed PMID: 10601309.

Ishida K, Matsumoto T, Taguchi K, Kamata K, Kobayashi T. Protein kinase C delta contributes to increase in EP3 agonist-induced contraction in mesenteric arteries from type 2 diabetic Goto-Kakizaki rats. Eur J Physiol 2012;463:593–602. PubMed PMID: 22371141

Geraldes P, King GL. Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res 2010;106:1319–31 . PubMed PMID: 20431074.

Ghatta S, Nimmagadda D, Xu X, O'Rourke ST. Large conductance, calciumactivated potassium channels: structural and functional implications. Pharm Ther 2006;110(1):103–16. PubMed PMID: 16356551.

Gupta S, Chough E, Daley J, Oates P, Tornheim K, Ruderman NB, et al. Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity. Am J Physiol Cell Physiol 2002;282:560–6. PubMed PMID: 11832341.

Gupta S, McArthur C, Grady C, Ruderman NB. Role of endotheliumderived nitric oxide in stimulation of Na+-K+- ATPase activity by endothelium in rabbit aorta. Am J Physiol Heart Circ Physiol 1994;266:577–82.

Kizub IV, Pavlova OO, Johnson CD, Soloviev AI, Zholos AV. Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats. Br J Pharmacol 2010;159(8):1724–31. PubMed Central PMCID: PMC2925495.

Klymenko KI, Novokhatska TV, Kizub IV, Parshikov AV, Dosenko VE, Soloviev AI. PKC-δ isozyme gene silencing restores vascular function in diabetic rat. J Basic Clin Physiol Pharmacol 2014:1–9. PubMed PMID: 24468620.

Kowluru RA, Jirousek MR, Stramm L, Farid N, Engerman RL, Kern TS. Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases. Diabetes 1998;47:464–9. PubMed PMID: 11473058.

Lee J-H, Bahk J-H, Park S-H, Huh J. The diabetes-induced functional and distributional changes of the alpha 1-adrenoceptor of the abdominal aorta and distal mesenteric artery from streptozotocin-induced diabetic rats. Korean J Anesthesiol 2011;60(4):272–81. PubMed PMID: 21602978.

Loirand G, Guerin P, Pacaud P. Rho kinases in cardiovascular physiology and pathophysiology. Circ Res 2006;98:322–34. PubMed PMID: 23921309.

Lu T, Chai Q, Yu L, d'Uscio LV, Katusic ZS, He T, et al. Reactive oxygen species signaling facilitates FOXO-3a/FBXOdependent vascular BKchannel b1 subunit degradation in diabetic mice. Diabetes 2012;61(7):1860–8. PubMed Central PMCID: PMC4322788.

Lu T, Lee H-C. Impaired vascular BK channel function in type 2 diabetesmellitus. In: Croniger C, editor. Medical complications of type 2 diabetes. InTech; 2011. p. 55–70.

Mahmoudian M, Behnaz F, Rezaei E. Diabetes-induced changes in the contractility of the aorta and pA2 of nifedipine in the rat. Acta Diabetol 1996;33:114–7. PubMed PMID: 8870812.

Matsui T, Amano M, Yamamoto T, Chihara K, Nakafuku M, Ito M, et al. Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J 1996;15:2208–1 6. PubMed Central PMCID: PMC450144.

Mehta NN, Sheetz M, Price K, Comiskey L, Amrutia S, Iqbal N, et al. Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus. Cardiovasc Drugs Ther 2009;23:17–24. PubMed PMID: 18949545.

Miao L, Calvert JW, Tang J, Zhang JH. Upregulation of small GTPase RhoA in the basilar artery from diabetic (mellitus) rats. Life Sci 2002;71:1175–85. PubMed PMID: 12095538.

Mori A, Suzuki S, Sakamoto K, Nakahara T, Ishii K. Vasodilation of retinal arterioles induced by activation of BKCa channels is attenuated in diabetic rats. Eur J Pharmacol 2011;669(1–3):94–9. PubMed PMID: 21871885.

Mueed I, Zhang L, MacLeod KM. Role of the PKC/CPI-17 pathway in enhanced contractile responses of mesenteric arteries from diabetic rats to α-adrenoceptor stimulation. Br J Pharmacol 2005;146:972–82. PubMed PMID: 16205724.

Nauli SM, Williams JM, Akopov SE, Zhang L, Pearce WJ. Developmental changes in ryanodine- and IP3-sensitive Ca2+ pools in ovine basilar artery. Am J Physiol Cell Physiol 2001;281:1785–96.

Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol Cell Physiol 1995;268:799–822. PubMed PMID: 7733230.

Nobe K, Suzuki H, Nobe H, Sakai Y, Momose K. High-glucose enhances a thromboxane A2-induced aortic contraction mediated by an alteration of phosphatidylinositol turnover. J Pharmacol Sci 2003;92:267–82. PubMed PMID: 12890893.

Rainbow RD, Hardy ME, Standen NB, Davies NW. Glucose reduces endothelin inhibition of voltage-gated potassium channels in rat arterial smooth muscle cells. J Physiol 2006;575:833–44. PubMed PMID: 16825302.

Reddy LS, Sarojamma V, Ramakrishna V. RNAi in medicine: current and future perspectives. Biotechnol Mol Biol Rev 2006;1 (4):103–14.

Rondinone CM. Therapeutic potential of iRNA in metabolic diseases. Biotechniques 2006;40:31–6.

Schofield AV, Bernard O. Rho-associated coiled-coil kinase (ROCK) signaling and disease. Crit Rev Biochem Mol Biol 2013;48(4):301–16. PubMed PMID: 23601011.

Schubert R, Lidington D, Bolz SS. The emerging role of Ca2+ sensitivity regulation in promoting myogenic vasoconstriction. Cardiovasc Res 2008;77:8–18. PubMed PMID: 17764667.

Senba S, Eto M, Yazawa M. Identification of trimeric myosin phosphatase (PP1M) as a target for a novel PKC-potentiated protein phosphatase-1 inhibitory protein (CPI17) in porcine aorta smooth muscle. J Biochem (Tokyo) 1999;125:354–62. PubMed PMID: 9990134.

Sledz CA, Williams BRG. RNA interference in biology and disease. Blood 2005;106(3):787–94. PubMed Central PMCID: PMC1895153.

Smith JM, Paulson DJ, Solar SM. Na+/K+-ATPase activity in vascular smoothmuscle from streptozotocin diabetic rat. Cardiovasc Res 1997;34:137–44.

Sobhia ME, Grewal BK, Bhat J, Rohit S, Punia V. Protein kinase C bII in diabetic complications: survey of structural, biological and computational studies. Expert Opin Ther Targets 2012;16(3):325–44.

Sobhia ME, Grewal BK, Paul SML, Patel J, Kaur A, Haokip T, et al. Protein kinase C inhibitors: a patent review (2008–2009). Expert Opin Ther Pat 2013;23(10):1297–315. PubMed PMID: 23795914.

Soliman H, Gador A, Lu Y-H, Lin G, Bankar G, MacLeod KM. Diabetes-induced increased oxidative stress in cardiomyocytes is sustained by a positive feedback loop involving Rho-kinase and PKCβ2. Am J Physiol Heart Circ Physiol 2012;303(8):989-1000. PubMed PMID: 22865386.

Somlyo AP, Somlyo AV. Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 2003;83:1325–58. PubMed PMID: 14506307.

Straub SV, Girouard H, Doetsch PE, Hannah RM, Wilkerson MK, Nelson MT. Regulation of intracerebral arteriolar tone by Kv channels: effects of glucose and PKC. Am J Physiol Cell Physiol 2009;297:788–96. PubMed PMID: 19605735.

Su W, Guo Z, Randall DC, Cassis L, Brown DR, Gong MC. Hypertension and disrupted blood pressure circadian rhythm in Type 2 diabetic db/db mice. AmJ Physiol Heart Circ Physiol 2008;295:1634–41. PubMed PMID: 18708447.

Swärd K, Mita M, Wilson DP, Deng JT, Susnjar M, Walsh MP. The role of RhoA and Rho-associated kinase in vascular smooth muscle contraction. Curr Hypertens Rep 2003;5(1):66–72. PubMed PMID: 12530938.

Uprichard SL. The therapeutic potential of RNA interference. FEBS Lett 2005;579:5996–6007.

Wang R, Wu Y, Tang G, Wu L, Hanna ST. Altered l-type Ca2+ channel currents in vascular smooth muscle cells from experimental diabetic rats. Am J Physiol Heart Circ Physiol 2000;278:714–22.

White RE, Carrier GO. Vascular contraction induced byactivation of membrane calcium ion cannelsis enhanced in streptozotocin-diabetes. J Pharmacol Exp Ther 1990;253(3):1057–62. PubMed PMID: 1694242.

Xia P, Kramer RM, King GL. Identification of the mechanism for the inhibition of Na+–K+–ATPase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2. J Clin Invest 1995;96:733–40. PubMed Central PMCID: PMC185257.

Xie Z, Su W, Guo Z, Pang H, Post SR, Gong MC. Up-regulation of CPI-17 phosphorylation in diabetic vasculature and high glucose cultured vascular smooth muscle cells. Cardiovasc Res 2006;69:491–501. PubMed PMID: 16336954.




DOI: http://dx.doi.org/10.17721/2616_6410.2016.21.61-66

Refbacks

  • There are currently no refbacks.


Лицензия Creative Commons
This journal is available according to the Creative Commons License «Attribution» («Атрибуція») 4.0 Global (CC-BY).