Endotoxication indicators in the blood of patients with ischemic stroke complicated by type two diabetes mellitus

T. Tsarenko, L. Gayda, O. Kravchenko
Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv

Abstract


Diabetes is one of the generally accepted factors of acute cerebral blood flow disorders. Numerous studies have shown involvement of many factors in the pathogenesis of diabetic cerebral disorders, the most important of which are the metabolic changes, including endotoxication. The aim of this study was to measure the endotoxication parameters and total protein and albumin contents in the blood of patients with ischemic stroke and patients with stroke complicated by type 2 diabetes. Also the average sex, age of the patients, body mass index (BMI) and blood glucose and lipoproteins levels, different disease complication presents and NIH Stroke Scale with Barthel index were determined. The investigation had shown that patients with ischemic stroke, including complicated by insulin independent diabetes, were characterized by
hypoproteinemia with the absence of marked changes of albumin content. The middle mass molecule (MSM) and oligopeptide contents revealed the presence of endogenous intoxication. These parameters, exceeding the control by 1.5 times, were high independently of hyperglycemia presence.
The results also allowed to establish differences in BMI, hyperlipoproteinemia and increasing of NIHSS in patients with ischemic stroke and diabetes mellitus type 2 comparing with stroke alone. Thus, the development of ischemic stroke separately and under conditions of type II diabetes was characterized by increasing rates of endotoxication (middle mass molecule and oligopeptides contents) in the blood of patients, that with hypoproteinemia and hyperlipidemia may cause the secondary pathobiochemical changes in the head brain cells and mediate the negative effects of acute disorders of cerebral blood circulation.

Keywords


ischemic stroke, type 2 diabetes, middle mass molecules, oligopeptides, endotoxication, body mass index

Full Text:

PDF>PDF

References


Vedunova M.V. [Status of endogenous intoxication in the metabolic syndrome and its correction low doses of ozone] Abstract. Dis. of PhD – 2008. -27s. Russian.

Gabrielyan N I [Screening method of middle molecules in biological fluids] Guidelines. – M., 1985. S. 11. Russian.

Gunas І.V. [The dynamіc of changes of endogenic intoxication in experimental rat burns] Ukrainsky morfologіchny almanach. – 201 2. – Volume 10, number 4. – S. 29-34. Ukranian.

Eleev M.A.-K. [Status prooxidant blood system and the level of middle mass molecules in patients with stroke] Bulletin of new medical technologies – 2013 – N 1. – 17-22. Russian.

Zabolotniy D. I. [Patologіcal effects of іntoxication cell membranes endogen peptides] Journal. NAMS of Ukraine. – 2011 – 17 v/# 3. – Pp 201-207. Ukranian.

Kopytova T V [The molecules of average weight as a substrate of endogenous intoxication in severe dematoses] The successes of modern science. – 2006. – number 9 – S. 7-10. Russian.

Krotenko N M [The middle mass molecules and antibodies to native and denatured DNA in patients with different types of sclerosis] Basic Research. – 2012. – number 5 – pp 305-310. Russian.

Kulmatitsky A. V. [Free radical oxidation and endogenous intoxication in acute ischemic stroke during the primary ischemic stroke] Endovascular neuroroentgenosurgery. – 2013. -№ 6- S. 17-22.9 Ukranian.

Nikolskaya V.A. [Biochemical aspects of the consideration of the role of middle mass molecules in the body] Scientific notes of Taurida National University. Vernadsky Series "Biology, Chemistry. – 2013 – 26 m, # 1. – Pp 139-145. Russian.

Nikolskaya V.A. [Change processes of oxidative modification of proteins and the level of middle mass molecules in patients with adrenal insufficiency, accompanied by hyperinsulinemia] Scientific notes of Taurida National University. Vernadsky Series "Biology, Chemistry". – 2010. – # 1 – S. 84-90. Russian.




DOI: http://dx.doi.org/10.17721/2616_6410.2016.21.57-61

Refbacks

  • There are currently no refbacks.


Лицензия Creative Commons
This journal is available according to the Creative Commons License «Attribution» («Атрибуція») 4.0 Global (CC-BY).