Growth and development of F1 male rat organism and its' immunophysiological activity in the period of watering with different doses of nanotechnologically and chemically synthesized germanium citrate

M. Khrabko, R. Fedoruk
Institute of Animal Biology of NAAS; Institute of Animal Biology of NAAS

Abstract


The aim of research was to study the effect of different doses of Ge citrate on the growth and development of F1 male, the activity of their
immune system and the state of hemostasis under these conditions. Research performed by methods of groups and periods with using F1 male
rats, which were watering during the milk-feeding period up to 120 days with Ge citrate obtained by nanotechnology method in doses 10 (I), 20 (II), 200 (III) mcg Ge/kg body weight and chemically synthesized Ge citrate in dose 2,000 (IV) mcg Ge/kg body weight. According to the research findings the most pronounced effect watering of Ge citrate on the growth and development of male rats organism was noted in dose 20 mcg Ge/kg body weight. Biological action of Ge citrate stimulated the immunophysiological activity of the organism with increasing of total Ig, molecules of average mass, sialic acid, number of white blood cells by the increasing number of lymphocytes and granulocytes, against the background of reduction of circulating immune complexes and hexoses bound to proteins. The positive dose-dependent effect of Ge citrate on the growth and development of the rats' organism and its immunophysiological and hematological parameters was noted.


Keywords


immunophysiology, rats, blood, tissue, germanium citrate

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DOI: http://dx.doi.org/10.17721/2616_6410.2016.21.39-43

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