Features of the bradykinin-induced contraction of the gastric smooth muscle depending on the concentration of compounds based on 3-substituted-1,4-benzodiazepin-2-ones

P. Virych, O. Shelyuk, V. Martynyuk, V. Pavlovsky
Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; A. V. Bogatsky Physico-Chemical Institute NAS of Ukraine, Odesa

Abstract


The effect of compounds based on 3-substituted-1,4-benzodiazepine-2-ones on contractile activity of smooth muscles of the rat's stomach was analyzed. Action substances MX-1626, MX-1775 for the smooth muscle contraction of like competitive inhibitor of bradykinin – des-Arg9- [Leu8]-Bradykinin acetate, which is observed as increase normalized rate of contraction with increasing of bradykinin concentration and characterized by a slowdown in the first phase of contraction. The most effective 3-subtituted 1,4-benzodiazepin-2-ones was at low concentrations of bradykinin, increasing it concentration their effect is reduced.

Keywords


smooth muscle, mechanokinetic parameters, 3-subtituted-1,4-benzodiazepine-2-ones

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References


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DOI: http://dx.doi.org/10.17721/2616_6410.2016.21.19-23

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