Biochemical parameters of the functional state liver in patients with hepatitis Under conditions of SARS-CoV-2 coinfection

Abstract

The COVID-19 pandemic started at the end of 2019 in China. It is spreading to all continents in a few months and continuing to this day. It shows a serious threat to the healthcare system around the world, because it is necessary to provide intensive care to a previously unthinkable number of patients. Although SARS-CoV-2 causes damage to the respiratory system, research shows that COVID-19 is a hidden enemy for our body, as a result of which other organs also suffer, in particular the liver. In the literature, over a short period of the pandemic, little scientific information has accumulated regarding changes in the biochemical parameters of the liver during the development of COVID-19. Our study focused on the clinical diagnosis of patients suffering from hepatitis B and infected with SARS-CoV-2, additionally, a study was conducted of persons suffering from COVID-19 and patients with the development of hepatitis B, and a comparison of the study groups was carried out to identify relationships. links between SARSCoV- 2 infection and HBV progression. We found that in patients with hepatitis B with SARS-CoV-2 coinfection, significant deviations from the physiological norm of such parameters of liver functioning as ALT, AST, total and direct bilirubin, were observed, however, such indicators as GGT were in the limit values of the norm. and alkaline phosphatase. Our study demonstrates the need for careful monitoring of patients with hepatitis B with SARS-CoV-2 coinfection, and it is also recommended to conduct additional clinical diagnosis of such groups of patients to identify other parameters of pathological conditions and to improve diagnostic/treatment approaches in high-risk groups of patients infected with SARS-CoV-2.