Blood coagulation parameters in pregnant women with COVID-19

D. Krenytska, A. Rachkovska, O. Savchuk, V. Karbovskiy
Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; LLC "Biopharma Plasma", Bila Tserkva

Abstract


The CoViD-19 pandemic have been lasting since 2019 year. It is a serious threat for health care system around the world because a huge number of patients requires of intensive assistance. Firstly, SARS-CoV-2 causes damage of the respiratory system. However, researches demonstrate that CoViD-19 is the hidden enemy for our body. It causes suffering of other organs. Coagulopathy often develops in SARS-CoV-2 patients. It includes acute inflammation, hypercoagulation and violation of the integrity and functions of the endothelium. A lot of scientific information has accumulated about changed in the hemostatic system during deveploment of CoViD-19. However, clinical researches are ambiguous, but abnormal blood clotting is demonstrated in most hospitalized patients with acute CoViD-19. Our research is aimed to analyse the main parameters of the hemostatic system in the pregnant women with infection of SARS-CoV-2 and the comparison with conventionally healthy pregnant patients. We have revealed the concentration of fibrinogen is increasing by 2,1 g/L, levels of D-dimer are increased by 500 ng/mL, the prothrombic time is rising by 1,2 seconds in plasma of the CoViD-19 pregnant patients unlike by conventionally healthy pregnant patients. Changes in the duration of activated partial thromboplastin time weren`t detected in plasma of the CoViD-19 pregnant patients unlike by conventionally healthy pregnant patients. Our research could be useful for diagnostic complications of the hemostatic system in CoViD-19 patients, for detection of blood clotting disorders during early stages of development, suppression of the spread of pathological processes of the fetus in pregnant women and for creation of effective treatment.

Keywords


SARS-CoV-2, the hemostatic system, coagulopathy, pregnant women

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Received: 06.09.2021

Revised: 05.10.2021

Signed for publishing: 06.10.2021




DOI: http://dx.doi.org/10.17721/1728_2748.2021.86.34-39

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