Serum peptide fraction of patients with myocardial infarction and various forms of angina

T. Marynenko, T. Halenova, O. Savchuk
Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv

Abstract


Today, there is a growing worldwide trend of coronary heart disease, which is the most common cause of death among the working population. Along with the development of effective drugs, no less acute is the question of improving the means of diagnosing coronary heart disease, as well as means of monitoring the course of the disease and the effectiveness of its treatment. Given that angina is often the first clinical manifestation of coronary heart disease, it is important to study and identify early markers of this pathological condition. A promising direction in this context may be the study of the dynamics of changes in the peptide profile in the bloodstream of patients with various forms of angina and myocardial infarction, the second most important manifestation of coronary heart disease. The results showed that myocardial infarction, as well as various forms of angina, is accompanied by the accumulation in the bloodstream of patients of proteins and peptides. Chromatographic separation of peptide fractions obtained from the serum of patients of different experimental groups was performed. It was found that in the bloodstream of patients with myocardial infarction and various forms of angina, there were not only quantitative changes in the peptide pool, but also the accumulation of peptides that are atypical for the physiological state of the organism. On the one hand, such peptides may have effector properties and be involved in inhibiting the
progression of the pathological condition and contributed to the normalization of homeostasis. On the other hand, the circulation of such peptides in the bloodstream may pose a potential threat of triggering non-specific mechanisms aimed at intensifying the pathological process. Further research is needed to confirm one of this hypothesis.

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Received: 04.05.2021

Revised: 03.06.2021

Signed for the press: 04.06.2021




DOI: http://dx.doi.org/10.17721/1728_2748.2021.85.23-26

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