Parameters of hemostatic potential in various stages of bladder cancer

A. Vasylaki, V. Dmytryk, T. Luhovska, P. Yakovlev
ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; O. Bogomolets National Medical University, Kyiv


Bladder cancer is characterized by a high mortality rate and is the 9th most common cancerous disease in the world. With a wide array of diagnostic bases, which include cystoscopy, ultrasound, computer and magnetic resonance imaging, cytology of urine deposition, it is difficult to accurately determine the extent of development of the tumor. It is important to find molecular and biochemical predictive parameters that would be characterized by high specificity and sensitivity to the tumor development. According to modern scientific data, an imbalance in the coagulation system is observed in cancer patients, the manifestation of which is the activation of the blood clotting system. Activation of the hemostatic system is accompanied by the appearance in the bloodstream of specific markers that reflect increase the hemostatic potential of the blood, such as the level of fibrin, fibrinogen, prothrombin time, activated partial thromboplastin time, activated plasma recalcification time. The results of a study of various cancers indicate an increased level of components of the plasminogen activation system, including the inhibitor of plasminogen activator-1 (PAI-1). The literature data that would indicate the prognostic significance of changes in the parameters of the blood clotting system and the proteolytic system in the blood in bladder cancer are few and have not completed. There are no data indicating the link between the studied parameters with histopathological gradation. In a detailed review of markers, it is possible to identify the optimal combination of markers of pathological processes, including the pathogenesis of oncological processes at various stages. During the study, we have investigated a significant increase in the level of fibrin, fibrinogen, and PAI-1, depending on the degree of bladder cancer. The test scores can make a significant contribution to the characterization of bladder cancer, depending on the grade according to the histopathological classification.


bladder cancer, hemostasis, fibrin, fibrinogen, PAI-1

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Received in the editorial: 10.09.2018

Received a revised version: 15.10.2018

Signed in the press: 15.10.2018


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