The rat blood glutathione system under obesity development with the compatible consumption of the kidney bean (Phaseolus vulgaris) pods extract

A. Yurchenko, D. Krenytska, M. Tymoshenko
Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv; Taras Shevchenko National University of Kyiv, Kyiv

Abstract


The state of the glutathione-dependent link of the antioxidant blood system of rats under obesity development and with the compatible consumption of the kidney bean (P. vulgaris) pods extract was studied.  Glutathione system forms functional basis of organism antioxidant defense system and disturbances in its work can lead to a number of serious cytotoxic and destructive lesions. Glutathione system constituent elements has its own glutathione and enzymes, which catalyze the reaction of its reverse transformation. These include glutathione peroxidase, glutathione transferase, and glutathione reductase. It is known that the water kidney bean (P. vulgaris) pods extract has hypoglycemic properties. However, complex studies of the polyfunctional action of this extract in obesity are absent. The obtained results indicate a decrease in the overall potential of the glutathione system in animals on a high-calorie diet. It has been established that glutathione peroxidase activity (GP) decreases in the serum of rats under experimental obesity, also glutathione transferase (GT) and glutathione reductase (GR) activity increase compared to the corresponding values in control animals. Our results demonstrated the concentration decrease of recovered glutathione (GSH) under consumption of high-calorie diet compared to the control. The findings after 6-th weeks of kidney bean (P. vulgaris) pods extract consumption indicate the positive modulating effect of this extract on the content of GSH and the activity of GP, GT and GR in rats with the obesity development. Probably, the consumption of this extract leads to attraction of the investigated components of the antioxidant system to the reactions of neutralization of toxic free radical compounds that were formed against the background of the development of obesity. Further studies may serve as the basis for the development of new therapeutic or medicinal preparations that based on the kidney bean (P. vulgaris) pods extract, because of still no consensus on the treatment of obesity.

Keywords


obesity, kidney beans pods extract, high-calorie diet, glutathione system

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References


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Received in the editorial: 03.10.2018

Received a revised version: 04.10.2018

Signed in the press: 04.10.2018


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