CHARACTERISTICS OF IMMUNE RESPONSE UNDER EXPERIMENTAL MODELS OF ACID BURNS OF THE ESOPHAGUS

T. Koval, T. Ischuk, Ya. Raetska
Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine; Taras Shevchenko National University of Kyiv, Kyiv, Ukraine

Abstract


It is well known that the immune system is actively involved in the regeneration and healing process of burn wounds. However, unanswered questions remain about the role of humoral immunity in the mechanisms of healing and complications of burn wounds. We have developed an experimental model of the acid burns of the esophagus (ABE) corresponding esophageal burns in children 1-8 years. We studied the features of humoral immunity in rats with AВE, with the observed reduction of IgG and increase levels of medium and low circulating immune complexes (CIC) on the first day after the burn of the esophagus. On 21st day after the burn, we observed an increase in the concentration of IgG and a slight accumulation of medium- and low-CIC. Studied indicators can be used for the differentiation of ABE.

Keywords


acid burns of the esophagus, IgG level, level of circulating immune complexes (CIC).

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References


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