ANTIVIRAL AND IMMUNOSTIMULATORY POTENTIAL OF FLUORINE CONTAINING TRIAZOLES

K. Naumenko, A. Golovan, G. Baranova, S. Zagorognya, Yu. Shermolovytch
D.K. Zabolotny Institute of Microbiology and Virology of NAS of Ukraine, Kiev, Ukraine; D.K. Zabolotny Institute of Microbiology and Virology of NAS of Ukraine, Kiev, Ukraine; D.K. Zabolotny Institute of Microbiology and Virology of NAS of Ukraine, Kiev, Ukraine; D.K. Zabolotny Institute of Microbiology and Virology of NAS of Ukraine, Kiev, Ukraine; D.K. Zabolotny Institute of Microbiology and Virology of NAS of Ukraine, Kiev, Ukraine

Abstract


The problem of finding effective antiviral drugs caused high morbidity and wide spread of viral infections. The purpose of this study was to investigate of antyherpetic activity fluorinated nucleoside G8 and G9 compounds (2-N-substituted-4-tosyl-5polyfluoroalkyl-1,2,3-triazole) in in vivo models and determine their immunomodulatory potential. Shown significant inhibition of virus reproduction under the influence of the compounds at concentrations of 0.4 and 0.5 mg/kg, which was more effective of acyclovir. Protection ratio amounted to 80%. Increasing level of IFN-γ and IL-2 in serum of animals, indicated available immunomodulatory effect fluorinated nucleoside compounds. Our studies indicated that there is antiherpetic, immunomodulatory activity of fluorine containing triazole and there is need to in-depth study of the mechanisms of this process.

Keywords


HSV-1, fluorinated nucleoside, antiherpetic activity

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References


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